Université Laval
Faculté de pharmacie

Répertoire du personnel

Alexandre Caron

Professeur adjoint

alexandre.caron@pha.ulaval.ca

Formation

Baccalauréat en biologie médicale (Université du Québec à Trois-Rivières) – 2007-2010

Maîtrise en physiologie-endocrinologie (Université Laval) – 2010-2011

Doctorat en physiologie-endocrinologie (Université Laval) – 2012-2015

Post-doctorat en neurométabolisme (University of Texas Southwestern Medical Center, Dallas, Texas, USA) – 2015-2020

Enseignement

Recherche

  • Mécanismes par lesquels le cerveau contrôle le métabolisme énergétique;
  • Développement de stratégies pharmacologiques permettant de traiter les maladies et désordres métaboliques (diabète, résistance à l’insuline, obésité, stéatose hépatique);
  • Définition des mécanismes physiopathologiques qui altèrent la communication cerveau-organes dans les maladies métaboliques;
  • Caractérisation des voies de signalisation des récepteurs couplés aux protéines G dans les organes métaboliques;
  • Développement de combinaisons pharmacologiques efficaces pour améliorer le métabolisme du glucose et des lipides.

Prix et distinctions

  • Rolls-Simons Award, The Obesity Society (2019)
  • Junior Investigator Award, Journal of Lipid Research (2019)
  • Keystone Symposia Scholarship (2019)
  • Pathway to Independence Award (K99/R00), National Institute of Diabetes and Digestive and Kidney Diseases (2019-2020)
  • Bourse Post-doctorale Banting (2018-2020)

Publications

Toutes les publications :
Google Scholar
ORCID

Publications récentes (2018-2020)

Michael NJ, Caron A, Lee CE, Castorena CM, Lee S, Zigman J, Williams K, Elmquist JK. 2020. Mela-nocortin Regulation of Histaminergic Neurons via Perifornical Lateral Hypothalamic Melanocortin 4 Receptors. Molecular Metabolism. DOI: 10.1016/j.molmet.2020.01.020.

Mouchiroud M, Camire E, Aldow M, Caron A, Jubincille E, Turcotte L, Kaci I, Beaulieu M, Roy C, Labbe S, Varin TV, Genilas Y, Lamoth J, Trottier J, Mitchell O, Festuccia WT, Joubert P, Rose C, Karvella C, Barbier O, Marette A, Morissette M, Laplante M. The hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain and glucose homeostasis. Molecular Metabolism, 30:184-191. PMID: 31767170.

Zhao S, Zhu Y, Schultz RD, Li N, He Z, Zhang Z, Caron A, Zhu Q, Sun K, Xiong W, Deng H, Sun J, Deng Y, Kim M, Lee CE, Gordillo R, Liu T, Odle AK, Childs GV, Zhang N, Kusminski CM, Elmquist JK, Williams KW, An Z, Scherer PE, 2019. Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy. Cell Metabolism, 30 (4), 706-719.e6, PMID: 31495688.

Caron A, Reynolds RP, Castorena CC, Michael NJ, Lee CE, Lee S, Berdeaux R, Scherer PE, Elmquist JK, 2019. Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis. Molecular Metabolism, 27:11-21. PMID: 31279640. 

Mouchiroud M, Camire E, Aldow M, Caron A, Jubincille E, Turcotte L, Kaci I, Beaulieu M, Roy C, Labbe S, Varin TV, Genilas Y, Lamoth J, Trottier J, Mitchell O, Festuccia WT, Joubert P, Rose C, Karvella C, Barbier O, Marette A, Morissette M, Laplante M, 2019. The hepatokine Tsukushi is released in response to NAFLD and impacts on cholesterol homeostasis. JCI insight, 4(15). pii: 129492. PMID: 31391339.

Mercado LL*, Caron A*, Wang Y, Burton M, Gautron L., 2019. Identification of leptin receptor-expressing cells in the mouse nodose ganglion. Endocrinology, 160(5):1307-1322, PMID: 30907928.

Blanchard PG, Moreira RJ, de Castro E, Caron A, Cote M, Andrade ML, Oliveira TE, Ortiz-Silva M, Peixoto AB, Dias FA, Gelinas Y, Guerra-Saa R, Deshaies Y, Festuccia WT., 2018. PPAR? is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues. Metabolism, 89:27-38. PMID: 30316815.

Labbe SM*, Caron A*, Festuccia WT, Lecomte R, Richard D., 2018. Interscapular brown adipose tissue denervation does not promote the oxidative activity of inguinal white adipose tissue in male mice. American Journal of Physiology – Endocrinology and Metabolism, 315(5):E815-E824. PMID: 30153064.

Caron A, Briscoe D, Richard D, Laplante M., 2018. DEPTOR at the Nexus of Cancer, Metabolism and Immunity. Physiological Reviews, 98(3):1765-1803. PMID: 29897294.

Caron A, Dungan Lemko HM, Castorena CM, Fujikawa T, Lee S, Lord CC, Ahmed N, Lee CE, Holland WL, Liu C, Elmquist JK., 2018. POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels. eLife, 7:e33710. PMID: 29528284. 

Carter S, Miard S, Caron A, Salle-Lefort S, St-Pierre P, Anhe FF, Lavoie-Charland E, Blais-Lecours P, Drolet M, Lefebvre JS, Lacombe J, Deshaies Y, Couet J, Laplante M, Ferron M, Bosse Y, Marette A, Richard D, Marsolais D, Picard F., 2018. Loss of OcaB prevents age-induced fat accretion and insulin resistance by altering B lymphocyte transition and promoting energy expenditure. Diabetes, db170558. PMID: 29496744.

Caron A, Lee S, Elmquist JK, Gautron L., 2018. Leptin and brain–adipose crosstalks. Nature Reviews Neuroscience, 19(3):153-165. PMID: 29449715.

Yuan X, Caron A, Wu H, Gautron L., 2018. Leptin receptors expression in the mouse intracranial perivascular cells. Frontiers in Neuroanatomy, 12:4. PMID: 29410615.